Rejuran is a polynucleotide (PN) injectable treatment that works at a cellular level to repair, regenerate, and rejuvenate your skin from the inside out. Unlike treatments that add volume or relax muscles, Rejuran works by stimulating your body's own healing mechanisms.
Polynucleotides are fragments of DNA derived from salmon — chosen for their exceptional biocompatibility with human skin. When injected into the dermis, they activate fibroblasts (the cells responsible for producing collagen and elastin), triggering a cascade of natural repair and renewal.
Originally developed in South Korea, Rejuran has been a staple of Korean aesthetics for years and is now gaining significant traction in Australia. For clients in Newcastle and the Hunter Valley, Mirror Mirror Aesthetics is at the forefront of offering this advanced treatment.
The science behind Rejuran is what makes it different from nearly every other injectable treatment. Here is what happens at the cellular level:
This is why Rejuran is often described as a "skin healer" rather than a cosmetic treatment. It does not change your appearance in the way fillers or anti-wrinkle injections do — it improves the fundamental quality of your skin.
Key difference: Fillers add volume. Anti-wrinkle injections relax muscles. Rejuran heals and regenerates the skin itself. This makes it a powerful foundation treatment that enhances the results of everything else.
Understanding how Rejuran compares to other injectable treatments helps you make an informed decision about which approach is right for your concerns:
| Feature | Rejuran (PN) | Dermal Fillers | Skin Boosters |
|---|---|---|---|
| Primary action | Cellular repair & regeneration | Volume addition & contouring | Deep hydration |
| How it works | Stimulates fibroblasts, collagen | Hyaluronic acid gel fills space | Micro-doses of HA hydrate dermis |
| Best for | Skin quality, scarring, under-eyes | Cheeks, lips, jawline, temples | Fine lines, dehydrated skin, glow |
| Results visible | 2–4 weeks (builds over sessions) | Immediate (settles in 2 weeks) | 2–3 weeks |
| Duration | 6–12 months | 6–18 months | 6–12 months |
| Sessions needed | 3–4 initial, then maintenance | 1 (with top-ups) | 2–3 initial, then maintenance |
| Price range | $300–$600 per session | $500+ per syringe | $350–$500 per session |
Many clients achieve the best outcomes by combining treatments. For example, a course of Rejuran to improve overall skin quality alongside targeted dermal fillers for volume restoration creates results that are both structurally sound and luminous. See our full guide: Facial Rejuvenation in Newcastle.
Rejuran is remarkably versatile. The clients who benefit most include those with:
Rejuran is suitable for most skin types and ages. Younger clients (late twenties to thirties) use it for prevention and skin optimisation, while older clients benefit from its regenerative and repair properties.
Here is exactly what happens when you come to Mirror Mirror Aesthetics for a Rejuran treatment:
Skin assessment, medical history, and treatment plan
Topical anaesthetic applied for 20–30 minutes
Precise micro-injections into the dermis
Soothing serum applied, instructions provided
The injection technique matters enormously with Rejuran. It must be placed at the correct depth in the dermis — too shallow and you get visible bumps, too deep and the product loses efficacy. This is why practitioner skill and experience are non-negotiable.
Most clients describe the sensation as mild pinpricks — easily manageable with numbing cream. The under-eye area can be slightly more sensitive, but Cameron uses specialised techniques to minimise discomfort in this delicate zone.
Aftercare tip: Avoid makeup for 12 hours post-treatment. Small bumps at injection sites are normal and typically resolve within 24–48 hours. Avoid strenuous exercise, saunas, and alcohol for 24 hours.
Rejuran results are cumulative — they build with each session. Here is the typical timeline:
For maintenance, most clients return every 6–12 months for a single top-up session. This keeps the regenerative benefits active and maintains the ongoing collagen production that Rejuran triggers.
Downtime is minimal. Most clients return to work the same day. The small injection marks are easily concealed with makeup after 12 hours if needed.
Rejuran requires precise injection technique and thorough understanding of dermal anatomy. At Mirror Mirror Aesthetics, Cameron Holland, RN ensures:
Interested in learning about other treatment options? Read our guides on anti-wrinkle injections and facial rejuvenation.
Dermal filler adds volume to specific areas. Rejuran heals and improves the quality of your skin itself by stimulating collagen production at a cellular level. They serve different purposes and can complement each other effectively.
We typically recommend an initial course of three to four sessions spaced two to four weeks apart, followed by maintenance treatments every three to six months to sustain results.
Yes. Polynucleotide therapy is well-suited to all skin types and tones. During your consultation, we'll assess your skin and confirm it's the right treatment for your specific goals and concerns.
Book a complimentary consultation with our registered nurse. We\u2019ll discuss your goals and create a personalised treatment plan — no obligation.