Polynucleotides have rapidly emerged as one of the most scientifically compelling treatments in modern aesthetic medicine. Unlike many cosmetic treatments that mask or temporarily correct signs of ageing, polynucleotides work at the cellular level to genuinely regenerate skin tissue.
At their most basic, polynucleotides are chains of nucleotides — the building blocks of DNA. The polynucleotides used in aesthetic treatments are derived from purified salmon DNA (Oncorhynchus mykiss), which shares a remarkably similar structure to human DNA. Through an extensive purification process, all proteins and potential allergens are removed, leaving only the bioactive DNA fragments.
When injected into the skin, these fragments don't alter your genetics in any way. Instead, they act as biological signals that wake up your skin's repair machinery from within.
Understanding the mechanism behind polynucleotides helps explain why they produce such genuinely different results compared to other injectable treatments.
Polynucleotides bind to A2A purinergic receptors on fibroblast cell surfaces. Fibroblasts are the cells responsible for producing collagen, elastin, and glycosaminoglycans — the structural components that keep skin firm, elastic, and hydrated.
Once activated, fibroblasts increase production of extracellular matrix components. In simpler terms, they start rebuilding the scaffolding that gives your skin its structure. This process also improves tissue hydration and reduces chronic inflammation.
Over weeks, the cumulative effect is genuine tissue regeneration — not just cosmetic improvement. Skin becomes measurably thicker, more elastic, and better hydrated at a structural level.
The key difference: Fillers add something to your face. Anti-wrinkle injections relax muscles. But polynucleotides stimulate your skin to heal and rebuild itself. The results develop gradually as new collagen forms, and they continue improving with each session.
Scientific note: Published studies have demonstrated measurable improvements in skin elasticity (up to 33% increase), hydration levels, and dermal thickness following polynucleotide treatment courses. These aren't just cosmetic observations — they're objective, measurable biological changes.
One of the most common questions is how polynucleotides compare to other injectable treatments. The answer: they serve fundamentally different purposes and work through entirely different mechanisms.
Many clients achieve the best results by combining treatments. For example, polynucleotides for cellular-level skin quality paired with dermal fillers for structural volume creates a comprehensive rejuvenation approach. Read our detailed comparison: skin boosters vs fillers.
Polynucleotides are versatile and can be used across multiple facial and body zones. The thin, delicate skin in certain areas responds particularly well to the hydrating and regenerative effects.
| Area | Key Benefit | Sessions | Ideal For |
|---|---|---|---|
| Under-eyes | Reduces dark circles, firms crepey skin | 3–4 | Hollow, tired-looking eyes |
| Full face | Overall texture, elasticity, glow | 3–4 | General skin ageing |
| Neck | Firms lax skin, reduces horizontal lines | 3–4 | Neck ageing, crepiness |
| Décolletage | Sun damage repair, texture improvement | 3–4 | Sun-damaged chest skin |
| Acne scarring | Stimulates repair of scar tissue | 4–6 | Rolling and atrophic scars |
| Hands | Improves skin quality and hydration | 3–4 | Ageing, thin hand skin |
Most popular area: The under-eye zone is where polynucleotides truly shine. The thin, delicate skin here doesn't always respond well to filler, but polynucleotides improve hydration, reduce darkness, and firm the tissue without adding volume. It's a game-changer for tired-looking eyes. Learn more in our tear trough treatment guide.
Knowing what happens at each stage removes uncertainty and helps you prepare for the best possible experience.
Skin assessment, goal setting, treatment planning
Topical anaesthetic applied 20–30 mins before
Series of micro-injections across the treatment area
Small bumps resolve in 24–48 hrs. Avoid makeup 12 hrs
Next session booked 2–4 weeks later
The treatment involves a series of micro-injections across the treatment area. It's well-tolerated by most clients, with minimal discomfort. You may notice small bumps at the injection sites immediately afterwards — these typically resolve within twenty-four to forty-eight hours. There's no significant downtime, though we recommend avoiding makeup for twelve hours post-treatment.
Patience is key with polynucleotides. Unlike filler where you see results immediately, polynucleotide results build gradually as your skin's cellular machinery responds to the treatment.
| Timeframe | What You'll Notice |
|---|---|
| Week 1–2 | Initial hydration boost, slight glow. Injection bumps resolve. |
| Week 3–4 | Improved skin texture. Fine lines begin softening. Second session. |
| Week 6–8 | Visible improvement in elasticity and firmness. Third session. |
| Month 3 | Peak collagen production. Skin noticeably firmer, smoother, more radiant. |
| Month 4–6 | Ongoing improvement as collagen remodelling continues. |
| Month 6–12 | Maintenance phase. Consider maintenance session to sustain results. |
Cumulative results: Most clients begin to notice improved skin texture and hydration after their first session, with optimal results after a course of three to four treatments. The improvements continue for several months after the final session as new collagen continues to form.
Polynucleotide therapy is well-suited to all skin types and tones. You may be an ideal candidate if you're experiencing:
Polynucleotides pair beautifully with other treatments — many clients combine them with microneedling or anti-wrinkle injections as part of a comprehensive skin health plan. Read more about Rejuran in our detailed guide: Rejuran: The Next Generation of Skin Healing.
Yes. Polynucleotide-based treatments have been used in medicine for decades, including in wound healing and ophthalmology. The purification process removes all proteins and potential allergens, making adverse reactions extremely rare.
Most clients see optimal results after three to four sessions spaced two to four weeks apart. Maintenance treatments every three to six months help sustain the regenerative benefits long term.
They serve different purposes. Polynucleotides improve skin quality, texture, and hydration, while fillers add structural volume. For clients who want better skin quality without adding volume, polynucleotides are an excellent standalone option. For others, they complement filler treatments beautifully.
Book a complimentary consultation with our registered nurse. We\u2019ll discuss your goals and create a personalised treatment plan — no obligation.